DNA Damage and Repair in Light-Sensitive Human Skin Disease
نویسندگان
چکیده
منابع مشابه
DNA damage and repair of human skin keratinocytes concurrently exposed to pyrene derivatives and UVA light.
Polycyclic aromatic hydrocarbons (PAHs), a class of mutagenic environmental contaminants, insert toxicity through both metabolic activation and light irradiation. Pyrene, one of the most widely studied PAHs, along with its mono-substituted derivatives, 1-amino, 1-bromo, 1-hydroxy, and 1-nitropyrene, were chosen to study the effect of substituents on their phototoxicity, DNA damage and repair. B...
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Ultraviolet-B (UVB) (290-320 nm) radiation-induced cyclobutane pyrimidine dimers within the DNA of epidermal cells are detrimental to human health by causing mutations and immunosuppressive effects that presumably contribute to photocarcinogenesis. Conventional photoprotection by sunscreens is exclusively prophylactic in nature and of no value once DNA damage has occurred. In this paper, we hav...
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Skin cancer is unique among human cancers in its etiology, accessibility and the volume of detailed knowledge now assembled concerning its molecular mechanisms of origin. The major carcinogenic agent for most skin cancers is well established as solar ultraviolet light. This is absorbed in DNA with the formation of UV-specific dipyrimidine photoproducts. These can be repaired by nucleotide excis...
متن کاملDNA damage, DNA repair and disease
Damage to cellular DNA can result in the loss of genetic information, in cellcycle arrest or even in cell death. So DNA is constantly surveyed for the presence of lesions and appropriate responses are mounted: failure can lead to genomic instability, mutations and ultimately cancer. In the last few years, rapid progress has been made in understanding many aspects of DNA repair. For example, it ...
متن کاملAnalysis of ionizing radiation-induced DNA damage and repair in three-dimensional human skin model system.
Knowledge of cellular responses in tissue microenvironment is crucial for the accurate prediction of human health risks following chronic or acute exposure to ionizing radiation (IR). With this objective, we investigated the radio responses for the first time in three-dimensional (3D) artificial human skin tissue microenvironment after gamma-rays radiation. IR-induced DNA damage/repair response...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1970
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12280225